Invokana

Invokana

canagliflozin

Manufacturer:

Janssen

Distributor:

Zuellig Pharma
Concise Prescribing Info
Contents
Canagliflozin hemihydrate
Indications/Uses
Adjunct to diet & exercise to improve glycemic control in adult patients w/ type 2 DM for whom metformin is inappropriate due to contraindications or intolerance. Combination w/ metformin or sulfonylurea in adult patients w/ type 2 DM; combination w/ metformin & either sulfonylurea or pioglitazone in adult patients w/ type 2 DM; as add-on combination therapy w/ insulin (w/ or w/o metformin) in adult patients w/ type 2 DM.
Dosage/Direction for Use
Initially 100 mg once daily, may be increased to 300 mg once daily if necessary.
Administration
May be taken with or without food: Take preferably before the 1st meal of the day.
Contraindications
Hypersensitivity. Patients w/ eGFR <60 mL/min/1.73 m2 or CrCl <60 mL/min.
Special Precautions
Not recommended for use in patients w/ type 1 diabetes. Not to be used for treatment of diabetic ketoacidosis. Patients at risk for AR related to vol depletion. Patients w/ already elevated haematocrit, galactose intolerance, Lapp lactase deficiency or glucose-galactose malabsorption. Moderate renal impairment. Not to be used during pregnancy & lactation.
Adverse Reactions
Hypoglycaemia in combination w/ insulin or sulphonylurea, vulvovag candidiasis, UTI, polyuria, pollakiuria.
Drug Interactions
Decreased exposure w/ cholestyramine. Add to the effect of diuretics, inulin & insulin secretagogues eg, sulphonylureas; enzyme inducers (eg, St. John's wort, rifampicin, barbiturates, phenytoin, carbamazepine, ritonavir, efavirenz). Increased AUC & Cmax of digoxin.
MIMS Class
Antidiabetic Agents
ATC Classification
A10BK02 - canagliflozin ; Belongs to the class of sodium-glucose co-transporter 2 (SGLT2) inhibitors. Used in the treatment of diabetes.
Presentation/Packing
Form
Invokana FC tab 100 mg
Packing/Price
30's
Form
Invokana FC tab 300 mg
Packing/Price
30's
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