Plasma/albumin-free recombinant coagulation factor VIII
Indications/Uses
Control & prevention of bleeding episodes & for surgical prophylaxis in patients w/ hemophilia A (congenital factor VIII deficiency/classic hemophilia). Xyntha does not contain von Willebrand factor & therefore is not indicated in patients w/ von Willebrand's disease.
Individualised dosage. Early hemarthrosis, minor muscle/oral bleeds 20-40 IU/dL 12-24 hrly for at least 1 day. Bleeding into muscles/oral cavity, mild head trauma 30-60 IU/dL 12-24 hrly for 3-4 days. GI, intracranial, intra-abdominal or intrathoracic bleeding, fractures 60-100 IU/dL 8-24 hrly. Minor surgery 30-60 IU/dL 12-24 hrly for 3-4 days. Tooth extraction 30-60 IU/dL single infusion + oral antifibrinolytic therapy w/in 1 hr. Major surgery 60-100 IU/dL 8-24 hrly.
Discontinue use if signs & symptoms of hypersensitivity reactions occur. Monitor for the development of factor VIII inhibitors. Pregnancy & lactation. Elderly ≥65 yr.
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