Xyntha

Xyntha

factor viii

Manufacturer:

Pfizer

Distributor:

Zuellig Pharma
Concise Prescribing Info
Contents
Plasma/albumin-free recombinant coagulation factor VIII
Indications/Uses
Control & prevention of bleeding episodes & for surgical prophylaxis in patients w/ hemophilia A (congenital factor VIII deficiency/classic hemophilia).
Dosage/Direction for Use
Individualised dosage. Early hemarthrosis, minor muscle/oral bleeds 20-40 IU/dL 12-24 hrly for at least 1 day. Bleeding into muscles/oral cavity, mild head trauma 30-60 IU/dL 12-24 hrly for 3-4 days. GI, intracranial, intra-abdominal or intrathoracic, fractures 60-100 IU/dL 8-24 hrly. Minor surgery 30-60 IU/dL 12-24 hrly for 3-4 days. Tooth extraction 30-60 IU/dL single infusion + oral antifibrinolytic therapy w/in 1 hr. Major surgery 60-100 IU/dL 8-24 hrly.
Contraindications
Hypersensitivity to coagulation factor VIII or hamster proteins.
Special Precautions
Discontinue use if signs & symptoms of hypersensitivity reactions occur. Monitor for the development of factor VIII inhibitors. Pregnancy & lactation. Elderly ≥65 yr.
Adverse Reactions
Headache, arthralgia, pyrexia, cough, diarrhea, vomiting, asthenia, nausea.
MIMS Class
ATC Classification
B02BD02 - coagulation factor VIII ; Belongs to the class of blood coagulation factors. Used in the treatment of hemorrhage.
Presentation/Packing
Form
Xyntha powd for inj (vial) 1000 IU
Packing/Price
1's
Form
Xyntha powd for inj (vial) 250 IU
Packing/Price
1's
Form
Xyntha powd for inj (vial) 500 IU
Packing/Price
1's
Form
Xyntha powd for inj (vial) 2000 IU
Packing/Price
1's
Register or sign in to continue
Asia's one-stop resource for medical news, clinical reference and education
Sign up for free
Already a member? Sign in