ampicillin + sulbactam




United Lab
Concise Prescribing Info
Powd for inj Per 750 mg Ampicillin 500 mg, sulbactam 250 mg. Per 1.5 g Ampicillin 1 g, sulbactam 500 mg
Resp tract infections including pneumonia, UTI including pyelonephritis, intra-abdominal including peritonitis, endometritis & pelvic cellulitis; bacterial septicemia; skin & skin structure infections including post-op wound infections, bone & joint, gynecological including gonococcal infections. Surgical prophylaxis including abdominal & pelvic surgical procedures.
Dosage/Direction for Use
Slow bolus IV Inj over at least 10-15 min. Adult Most infections Usual dose: 1.5 g-12 g/day in divided dose every 6-8 hr. IV/deep IM Mild infection 1.5-3 g every 6-8 hr. Moderate infection Up to 6 g every 6-8 hr. Severe infection Up to 12 g every 6-8 hr. Max: Sulbactam 4 g/day. Usual treatment duration:5-14 days. Surgical prophylaxis 1.5-3 g at induction of anesth, may be repeated every 6-8 hr for. Discontinue 24 hr after majority of surgical procedure. Uncomplicated gonorrhea 1.5 g as single dose w/ 1 g oral probenecid. Impaired renal function CrCl >30 mL/min 1.5-3 g every 6-8 hr, 15-29 mL/min 1.5-3 g every 12 hr, <15 mL/min 1.5-3 g every 24 hr. IV infusion Childn ≥1 yr &/or <40 kg 150 mg/kg/day in equally divided dose every 6-8 hr. Neonate (during 1st wk of life particularly in premature infant) 75 mg/kg/day in equally divided dose every 12 hr.
Special Precautions
Hypersensitivity reactions on penicillin therapy. Serious anaphylactoid reactions. Clostridium difficile-associated diarrhea & colitis. Patients w/ infectious mononucleosis. Overgrowth of nonsusceptible microorganism; discontinue if superinfection occurs.
Adverse Reactions
Anaphylactoid reaction & shock; diarrhea, nausea, vomiting, flatulence, abdominal discomfort or distention, rectal bleeding & glossitis, gastritis, stomatitis, black or hairy tongue, enterocolitis, pseudomembranous colitis; headache, dizziness, confusion, changes in smell or taste perception; urine retention, dysuria, increased BUN & creatinine, presence of RBC & hyaline casts in urine; bilirubinemia, abnormal hepatic function & jaundice; increased AST, ALT, alkaline phosphatase, & LDH; decreased Hb, hematocrit, RBC, WBC, neutrophils, lymphocytes, platelets; increased lymphocytes, monocytes, basophils, eosinophils & platelets; decreased serum albumin & total proteins; agranulocytosis; +ve direct Coombs' test; rash, itching, other skin reactions, Stevens-Johnson syndrome, epidermal necrolysis, urticaria, pruritus, dry skin, erythema, erythema multiforme, exfoliative dermatitis; pain at inj site, phlebitis, thrombophlebitis & inflammation at inj site; fatigue, malaise, chest pain or tightness, edema, facial swelling, chills, throat tightness, substernal pain, epistaxis & mucosal bleeding, acute hyperpyrexia, rapid defervescence after completion of the infusion, candidiasis.
MIMS Class
ATC Classification
J01CR04 - sultamicillin ; Belongs to the class of penicillin combinations, including beta-lactamase inhibitors. Used in the systemic treatment of infections.
Ampimax 1.5 g infusion
(vial) 10 × 1's
Ampimax 750 mg infusion
(vial) 10 × 1's
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