The following reactions have been reported with the use of clindamycin.
Abdominal pain, pseudomembranous colitis, esophagitis, nausea, vomiting and diarrhea. The onset of pseudomembranous colitis symptoms may occur during or after antibacterial treatment.
Generalized mild to moderate morbilliform-like (maculopapular) skin rashes are the most frequently reported adverse reactions. Vesiculobullous rashes as well as urticaria have been observed during drug therapy. Rare instances of erythema multiform, some resembling Stevens-Johnson syndrome and a few cases of anaphylactoid reactions have also been reported.
Skin and Mucous Membrane:
Pruritus, vaginitis and rare instances of exfoliative dermatitis have been reported.
Jaundice, hepatic damage and abnormalities in liver function tests have been observed during clindamycin therapy.
Although no direct relationship of clindamycin to renal damage has been established, renal dysfunction as evidenced by azotemia, oliguria and/or proteinuria hs been observed in rare instances.
Transient neutropenia (leucopenia) and eosinophilia, agranulocytosis and thrombocytopenia have been reported. No direct etiologic relationship to concurrent clindamycin therapy could be made in any of the foregoing.
Rare instances of polyarthritis have been reported.