Proton pump inhibitors, by decreasing gastric acidity, may increase the risk of gastro-intestinal infections.
Omeprazole (Zefxon) injection is generally well tolerated. The following events have been reported: Central and peripheral nervous system:
Headache, dizziness, paraesthesia, light headedness, feeling faint, somnolence, insomnia, vertigo, reversible mental confusion, agitation, aggression, depression, hallucinations (predominantly in severely ill patients).
Diarrhea, constipation, abdominal pain, nausea, vomiting, flatulence, dry mouth, stomatitis, gastrointestinal candidiasis.
leukopenia, thrombocytopenia, agranulocytosis, pancytopenia.
Increased liver enzymes, encephalopathy in patients with pre-existing severe liver disease; hepatitis with or without jaundice, hepatic failure increased liver enzymes.
Arthralgia, myalgia, muscular weakness.
Reproductive system and breast disorders:
Rash and/or pruritus, urticaria, photosensitivity, bullous eruption, erythema multiforme, Stevens-Johnson syndrome, toxic epidermal necrolysis (TEN), alopecia.
Malaise, Hypersensitivity reactions e.g. angioedema, fever, bronchospasm, interstitial nephritis and anaphylactic shock. Increased sweating, peripheral edema, blurred vision, taste disturbance, hyponatraemia.