Zycloran

Zycloran

chlorpromazine

Manufacturer:

Shandong Xier Kangtai

Distributor:

JF Draf
Concise Prescribing Info
Contents
Chlorpromazine HCl
Indications/Uses
Management of psychotic disorders including manifestations of manic depressive illness, schizophrenia. Control of nausea & vomiting. Relief of severe hiccups & acute intermittent porphyria. Adjunct in the treatment of tetanus.
Dosage/Direction for Use
Adult Initially 25-50 mg tid, increased if necessary. Doses of 75 mg may be given as single dose at night. Maintenance: 25-100 mg tid. Psychotic patient Up to ≥1 g. Nausea & vomiting 10-25 mg every 4-6 hr. Elderly & debilitated patient 1/3-1/2 the adult dose. Childn >5 yr (w/ psychiatric conditions) 1/3-1/2 the adult dose, 1-5 yr 500 mcg/kg every 4-6 hr. Max: 75 mg daily (for childn >5 yr) or 40 mg daily (for childn 1-5 yr).
Administration
May be taken with or without food: May be taken w/ meals to reduce GI discomfort.
Contraindications
Hypersensitivity. Comatose or depressed states due to CNS depressants; blood dyscrasias; bone marrow depression; liver damage. Childn or adolescents w/ symptoms suggestive of Reye's syndrome.
Special Precautions
Patients w/ impaired liver function, CV disease, chronic resp disorders, gastric ulcer, aggravation of preexisting ulcer. History of seizures. May intensify effects of alcohol & CNS depressants; impair sensitivity & adaptation to changes of environmental temp. May impair ability to drive or operate machinery. Women of childbearing potential. Pregnancy (1st trimester) & lactation.
Adverse Reactions
Blurred vision, dry mouth, constipation, ileus, nasal stuffiness, photophobia; hypotension, PR & QT prolongation, T-wave bluting & S-T segment depression; extrapyramidal reactions including pseudoparkinsonism, dystonic reactions & akathisia; dizziness; tardive dyskinesia; itching, skin rash, erythema, allergic purpura, exfoliative dermatitis, photosensitivity; increased prolactin secretion, gynecomastia, galactorrhea, mastalgia, altered libido, menstrual irregularities, wt gain, glucose tolerance alterations & false +ve pregnancy tests; nausea, vomiting, increase/decrease appetite, gastric irritation; urinary retention, priapism, inhibition of ejaculation; agranulocytosis, leukopenia, granulocytopenia, eosinophilia, thrombocytopenia, anemia, aplastic anemia, pancytopenia; jaundice; pigmentation of areas of conjunctiva &/or discoloration of the exposed sclera & cornea.
Drug Interactions
Reciprocal antagonism of dopaminergic antiparkinsonism agents (amantadine, bromocriptine, cabergoline, levodopa, lisuride, pergolide, piribedil, ropinirole), neuroleptic & levodopa. Increased risk of arrhythmias w/ QT prolonging drugs (including certain antiarrhythmics & other antipsychotics including sultopride) & drugs causing electrolyte imbalance. Potentiates sedative effect w/ alcohol. Confusional syndrome, hypertonia & hyperreflexicity w/ lithium (high doses). Increased blood sugar levels (decreased insulin release) w/ antidiabetic agents. Decreased GI absorption w/ topical GI agents (Mg, aluminum & Ca salts, oxides & hydroxides). Potentiates antihypertensive effect & risk of orthostatic hypotension (additive effects) w/ antihypertensive agents. Enhances hypotensive effect of anaesth & Ca channel blockers. Severe postural hypotension may occur w/ ACE inhibitors.
MIMS Class
Antipsychotics
ATC Classification
N05AA01 - chlorpromazine ; Belongs to the class of phenothiazine antipsychotics with aliphatic side-chain.
Presentation/Packing
Form
Zycloran tab 100 mg
Packing/Price
100's
Form
Zycloran tab 200 mg
Packing/Price
100's
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