Administer at a max rate of 10 mL/min. Adult & patients 12-18 yr
The doses & intervals may be considered based on achieved FVIII levels & individual bleeding tendency. Early haemarthrosis, muscle or oral bleeding
20-40 IU/dL. Repeat inj every 12-24 hr at least 1 day until bleeding episode is resolved or healing is achieved. More extensive haemarthrosis, muscle bleeding or haematoma
30-60 IU/dL. Repeat inj every 12-24 hr for 3-4 days or more until pain & acute disability are resolved. Life threatening haemorrhages
60-100 IU/dL. Repeat inj every 8-24 hr until threat is resolved. Minor surgery including tooth extraction
30-60 IU/dL every 24 hr at least 1 day until healing is achieved. Major surgery (pre- & post-op)
80-100 IU/dL. Repeat inj every 8-24 hr until adequate wound healing, then continue treatment for at least another 7 days to maintain a factor VIII activity of 30% to 60% (IU/dL). Long-term prophylaxis
40-50 IU/kg twice wkly in 3-4 day intervals.