Pristiq also contains the following inactive ingredients: Hypromellose, microcrystalline cellulose, talc, magnesium stearate. Film-Coating: Sodium carboxymethylcellulose, maltodextrin, dextrose, titanium dioxide, stearic acid and iron oxide(s).
Desvenlafaxine is RS-4-[2-dimethylamino-1-(1-hydroxycyclohexyl)ethyl]phenol and has the empirical formula of C16H25NO2 (free base) and C16H25NO2·C4H6O4·H2O (succinate monohydrate). Desvenlafaxine succinate monohydrate has a molecular weight of 399.48.
Desvenlafaxine succinate is a white to off-white powder that is soluble in water. The solubility of desvenlafaxine succinate is pH dependent. Its octanol:aqueous system (at pH 7) partition coefficient is 0.21.
Desvenlafaxine (O-desmethylvenlafaxine), a structurally novel serotonin and norepinephrine reuptake inhibitor (SNRI), is the major active metabolite of the antidepressant venlafaxine.